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The concept of “cortisol resistance” is more commonly referred to as glucocorticoid resistance. This condition involves a reduced sensitivity of tissues to the actions of glucocorticoids like cortisol. This is a condition where the body’s tissues exhibit a reduced sensitivity to glucocorticoids, such as cortisol. As a result, the hypothalamic-pituitary-adrenal (HPA) axis compensates by increasing the production of cortisol. Despite high levels of cortisol, the intended physiological effects are
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