1) Hydroquinone: Gold Standard Best Melanin Inhibitor Most powerful topical tyrosinase inhibitor available in dermatology practic 2) Rucinol Potent tyrosinase inhibitor with lower IC50 than kojic acid, hydroquinone, and arbutin meaning it blocks melanin production more effectively in lab assays. 3)Tranexamic Acid Blocks inflammatory pathways and melanocyte activation (beyond tyrosinase alone). Excellent for stubborn melasma & recurrent pigmentation. 4) Tretinoin / Retinoids Not a direct tyrosina
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