Gut

From pressure to prognosis: establishing a common language for portal hypertension in advanced chronic liver disease

Risk stratification in compensated advanced chronic liver disease has traditionally been based on the identification of ...
Gut

Replication of protein associations is not external validation of a fixed mortality score

Diambra and colleagues1 integrated metabolic dysfunction-associated steatotic liver disease phenotypes with proteomics to derive a four-protein mortality score (PS4: FTCD, FABP1, ADGRG1 and GAST). We ...
gut.bmj

Deferring first surveillance to 3 years after colorectal ESD is not supported by these data

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gut.bmj

Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation

Background Acetate is the metabolic precursor of acetyl-coenzyme A (CoA), fuelling histone acetylation. Objective We aimed to investigate whether the acetate-acetylation axis is hijacked in tumour ...
gut.bmj

Proteomic resolution of the MASLD cardiometabolic spectrum identifies sex-driven endotypes and predicts systemic mortality

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition where overlapping cardiometabolic risk factors challenge accurate prognostic prediction.
gut.bmj

Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study

Background New-onset diabetes (NOD) increases the risk of pancreatic cancer. Previous studies have mainly focused on the presence or absence of diabetes, with limited attention to NOD severity at ...
gut.bmj

Time to colonoscopy after a positive faecal immunochemical test: does self-selection bias explain a null result?

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gut.bmj

DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?

We read with great interest the recent study by Lau et al , who reported distinct intrahepatic hepatitis B virus (HBV) integration patterns according to HBeAg status and observed marked enrichment of ...
gut.bmj

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease

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gut.bmj

Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis

Background Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction, with some recommended treatments targeting brain-gut axis dysfunction. Objective To compare relative efficacy of ...
gut.bmj

Early high-energy enteral nutrition in acute pancreatitis: overfeeding and respiratory risk in high-risk patients

I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...
gut.bmj

From preclinical phase of Crohn’s disease to postoperative recurrence: shared mechanisms and potential interventions

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with high risk of surgery. Despite advances in medical treatment, of those patients who undergo ileocolonic ...