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Ginger for the treatment and prevention of migraine headaches: a systematic review and meta-analysis of randomised controlled trials

Objective To determine the efficacy of ginger (either stand-alone or as an adjunct treatment) for the treatment and management of migraine headaches. Methods We searched PubMed, Embase, CINAHL, ...
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Applying the estimand framework to safety: aligning estimators with treatment effects in the presence of intercurrent events

Understanding the risks associated with healthcare interventions is essential for clinical decision-making and for the regulatory evaluation of new drugs. Yet, safety analyses in randomised controlled ...
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Defining and interpreting the clinical relevance of intervention effects for patient-reported outcomes: the smallest worthwhile effect construct

In clinical research, statistically significant effects do not necessarily indicate that an intervention provides benefits that are meaningful to patients. This is particularly important for ...
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Improving inclusivity in UK clinical trials through good practice in the collection and use of ethnicity data: recommendations from the INCLUDED study

Ethnicity data are essential in understanding how different groups are impacted by different treatments/healthcare interventions, but more work is needed in how these data should be collected, handled ...
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Loss of an ideal: how politics and misinformed advocacy killed the Canadian Task Force

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Prediction models in clinical guidelines: a scoping review of clinical guideline guidance development documents

Objectives Probability or risk outcome estimates tailored to individual patient characteristics can facilitate more personalised care, for example, regarding treatment. Yet, the uptake of prediction ...
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Impact of prompt engineering on large language models for risk of bias assessment: a comparative study

Objectives To evaluate the performance of large language models (LLMs) in risk of bias assessment and to examine whether prompt engineering improves their accuracy and alignment with expert reasoning.
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Educating health professionals in evidence-based practice in 2026

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Equity and representativeness in pragmatic drug trials: methodological and ethical considerations

The WHO defines health equity as ‘the absence of unfair, avoidable or remediable differences among groups of people based on various dimensions of inequality (eg, sex, gender, ethnicity, disability or ...
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Correspondence on ‘Effectiveness and clinical relevance of kinesio taping in musculoskeletal disorders: an overview of systematic reviews and evidence mapping’ by Mo et al

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FDA approval of benzgalantamine exposes flaws in the 505(b)(2) pathway for innovations on existing drugs

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Advancing the ‘Choosing Wisely’ campaign to reduce low-value care in China

Jay Pan and colleagues stress that reducing low-value medical services and enhancing healthcare quality must be an urgent priority in China; advancing the Choosing Wisely initiative represents a ...