San Francisco 49ers running back Christian McCaffrey speaks with reporters before practice Thursday at the SAP Performance Facility in Santa Clara.Christian McCaffrey on 49ers continuing to win despit ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

And they both ended up competing for the No. 1 seed in a competitive conference the year after. In 2019, San Francisco was ...

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

The Indianapolis Colts can't lose to the San Francisco 49ers, or their playoff hopes will fall into the abyss.

Once Bosa was gone, Huff became the 49ers’ top pass rusher (by a wide margin). That meant two things: 1. Opponents started ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead ...