The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

Although 49ers receiver Ricky Pearsall reinjured the knee that kept him out of six games earlier this season, coach Kyle ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

The San Francisco 49ers might have a new face at linebacker when they visit the Indianapolis Colts in Week 16.

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.

The Indianapolis Colts can't lose to the San Francisco 49ers, or their playoff hopes will fall into the abyss.

Once Bosa was gone, Huff became the 49ers’ top pass rusher (by a wide margin). That meant two things: 1. Opponents started ...