The Indianapolis Colts will enter their Monday Night matchup against the San Francisco 49ers as the home underdogs. At 8-6 on ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

One prominent NFL insider named two teams that could potentially be interested in trading for San Francisco 49ers QB Mac ...

As the Indianapolis Colts look to keep their playoff hopes alive, up next for them is a home matchup with the San Francisco ...

That is, until now. Eddy Pineiro has been revolutionary for the 49ers and has been key to the 49ers' success this season.

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason ...

QB Mac Jones could draw major offseason trade interest after impressing in relief of Brock Purdy, according to an NFL insider ...

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran ...

The 49ers' offense is about the same as 2024. The defense is worse. The special teams, though, has taken a historic leap. Is ...

ESPN announced a major change for the Week 16 showdown between the San Francisco 49ers and Indianapolis Colts.