The San Francisco 49ers control their own destiny to grab the NFC's No. 1 playoff seed after the Seattle Seahawks' win over ...

Jones had both the highest completion percentage (69.6 percent) and yards per attempt (7.4) of his career during that stretch ...

ESPN's FPI simulation projects how the 49ers finish the 2025 season, their playoff seed, and how far San Francisco advances.

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

The San Francisco 49ers announced a minor roster move on Tuesday, releasing cornerback Isaiah Bolden from the practice squad.

One prominent NFL insider named two teams that could potentially be interested in trading for San Francisco 49ers QB Mac ...

That is, until now. Eddy Pineiro has been revolutionary for the 49ers and has been key to the 49ers' success this season.

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead ...

As the Indianapolis Colts look to keep their playoff hopes alive, up next for them is a home matchup with the San Francisco ...

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran ...

Two teams that could be interested? The Pittsburgh Steelers and Indianapolis Colts. The Steelers will likely be looking to ...

The 49ers' offense is about the same as 2024. The defense is worse. The special teams, though, has taken a historic leap. Is ...