Objective This study aimed to compare 25-hydroxyvitamin D (25-(OH)D) levels and peripheral lymphocyte subsets between ...

Objectives Cardiovascular disease is a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE), largely driven by endothelial dysfunction. Belimumab, a monoclonal antibody ...

The case for early biologic therapy in systemic lupus erythematosus (SLE) is intuitively appealing but requires closer scrutiny. First, ‘early’ is poorly defined with UK survey data showing a mean ...

Background The short-term and long-term outcome of inflammatory neuropsychiatric SLE (NPSLE) with immunosuppressive treatment is largely unknown. We used clinical data from our tertiary referral ...

Lupus nephritis (LN) remains one of the most severe organ manifestations of systemic lupus erythematosus, affecting up to 50% of patients and carrying substantial risk of progressive renal failure ...

In systemic lupus erythematosus (SLE), the term ‘immune reset’ is seductive but potentially too mechanical: it implies that autoimmunity can be switched off and the immune system returned to a ...

Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease characterized by exocrinopathy, extraglandular inflammation, and marked B-cell activation. Dryness, fatigue, pain, systemic organ ...

Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving dysregulated innate and adaptive immunity, with autoreactive B and T cells being central to its pathogenesis.

Objectives Composite criteria/indices are presently used to diagnose and monitor patients with systemic lupus erythematosus (SLE). Biomarkers for these purposes would be helpful in clinical practice.

Background Proliferating cell nuclear antigen (PCNA) antibodies are a rare type of antinuclear antibodies (ANA), historically considered highly specific for systemic lupus erythematosus (SLE). Recent ...

Objectives Voclosporin is approved for the treatment of adults with active lupus nephritis (LN). In the Phase 3 AURORA studies, voclosporin plus mycophenolate mofetil and low-dose glucocorticoids led ...

Objective Lupus nephritis (LN) is a potentially severe manifestation of SLE, often resulting in permanent kidney damage. We investigated whether polygenic and/or epigenetic risk is associated with ...