To enable more rational optimization of MVA-based vaccines, we developed a mechanistic and executable systems vaccinology framework based on Boolean modeling to capture the dynamics of vaccine-induced ...

The authors highlight three potential regulators - galectin 1, galectin 3, and Myc - providing solid evidence for potential roles in modulating the proliferation of cochlear GER cells using gene ...

This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further ...

Behavioural diversity across fruit flies changes with individual learning, even when genetic, past and momentary environmental factors are held constant.

Human spatial representations are often assumed to represent Euclidean properties such as length, distance, and angle. Here we test an alternative (but not mutually exclusive) possibility – that ...

This valuable study advances our understanding of habituation and related potentiation behavior in a single-celled organism, Stentor. The authors provide convincing evidence for their claims in the ...

In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced ...

The approach is solid, but the choice of learning rules, circuit architecture, and sparsity assumptions is not always sufficiently justified, and the model would benefit from a clearer mechanistic ...

This study presents valuable findings implicating Xkr and its newly identified binding partners in regulating the exposure of apoptotic signal for phagocytosis, suggesting that Xkr might facilitate ...

The study provides important insight into the development of CD8 T cell virtual memory cells by identifying a dose-sensitive role for Bcl11b. The authors define the developmental stages affected by ...

This valuable study combines free-flight kinematics, aerodynamic modeling, optogenetics, and connectomics to ask how Drosophila stabilize roll perturbations duri ...

This manuscript examines how overexpression of sphingosine 1-phosphate receptor 1 in a mouse model affects neutrophil distribution, metabolism and function. Given the significance of S1PR1 in ...