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Bills at Patriots: Predictions, picks and odds for NFL Week 15 game
The Buffalo Bills (9-4) visit the New England Patriots (11-2) at Gillette Stadium in Foxborough for a Week 15 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions ...

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Buffalo Bills at New England Patriots odds, picks and predictions
Patriots vs. Bills predictions, picks, and best bets for NFL Week 15
NFL Week 15 news, live updates: Packers DE Micah Parsons heads questionable with knee injury; Patrick Mahomes reportedly suffers torn ACL as Chiefs eliminated from playoff contention
Week 15 has a packed Sunday afternoon window with five games, headlined by an NFC showdown with plenty of playoff implications featuring the Detroit Lions and Los Angeles Rams.

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Fan Notes from the Patriots’ loss to the Bills
NFL Week 15 highlights: Best plays, moments, touchdowns
NFL Week 15 weather, news, live updates: Chiefs' Xavier Worthy in concussion protocol, Texans' Woody Marks questionable with ankle injury
Quarterback Philip Rivers, 44, is set to make his first start since the 2020 NFL season in relief of Daniel Jones, who suffered a ruptured Achilles in Week 14, ending his season.

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Buffalo Bills complete stunning comeback vs. Patriots to stay alive in AFC East race (observations)
Bills 35-31 Patriots (Dec 14, 2025) Game Stats - ESPN

Bills vs. Patriots prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

The Pats’ defense ranks Top 10 in many metrics. They are especially stout against the run, which could challenge the Bills and specifically, running back James Cook. The Bills’ bell cow back is the NFL’s second-leading rusher with 1,308yds (trails only Jonathan Taylor (1,356yds).

Bills vs. Patriots: Three Bold Predictions For Sunday’s AFC East Showdown in Foxboro

The NFL’s Week 15 slate will continue on Sunday afternoon with an epic, AFC East showdown taking place in Foxborough, Mass. Looking to secure their first division title since 2019, the Patriots will welcome the Bills to Gillette Stadium for a 1:00 p.m. ET kickoff.
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