The San Francisco 49ers secured a 27-7 win over the Los Angeles Rams in their historic Week 1 matchup at the Melbourne ...

Take a look at players who have been ruled out for the San Francisco 49ers Week 1 matchup versus the Los Angeles Rams.

Catch up on the latest San Francisco 49ers headlines, powered by Cisco.

The 49ers announced they have re-signed S Ashtyn Davis and P Corliss Waitman to one-year deals. In order to make room on the roster, the team placed CB Nate Hobbs and LB Nick Martin on the Injured ...

San Francisco 49ers head coach Kyle Shanahan provided injury updates for WR De'Zhaun Stribling, TE Jake Tonges, and others, ...

San Francisco 49ers QB Brock Purdy's best throws from his 3-TD game in Melbourne against the Los Angeles Rams during Week 1 ...

Watch the best plays by the San Francisco 49ers against the Los Angeles Rams in Week 1 of the 2026 NFL season.

San Francisco 49ers QB Brock Purdy, WR Mike Evans, TE George Kittle, LB Dre Greenlaw, WR Deebo Samuel Sr., RB Christian ...

The San Francisco 49ers released their latest injury updates headed into the season opener contest against the Los Angeles Rams.

San Francisco 49ers WR Mike Evans grabs his first catch as a 49ers player to give the team a first down in the Week 1 matchup ...

San Francisco 49ers K Eddy Piñeiro's 56-yard field goal extends the 49ers lead to 27-7 in the Week 1 matchup vs. the Los ...

San Francisco WR Deebo Samuel Sr. grabs a 15-yard touchdown pass from QB Brock Purdy in the Week 1 matchup vs. the Rams.