What makes every person unique? Part of the answer is in our genes.

A genetic deletion responsible for the rare “salmiak” pattern in cats has been identified, revealing new information about ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

IN THE POPULAR imagination, cancer starts with a mutation in the DNA of a normal cell. That mutation allows the cell to multiply uncontrollably, circumventing the body’s usual quality-control checks.

After decades of fixating on mutations in nuclear DNA as the prime suspects in cancer development, researchers are increasingly peering into the cell’s powerhouse for clues. Mutations in mitochondrial ...

G4 and R-loop signals at the indicated genomic locus. Both G4s and R-loops accumulate in cells where the resolution of G4 knots is defective (red). Not all DNA looks like the familiar twisted ladder.

Gear-obsessed editors choose every product we review. We may earn commission if you buy from a link. Why Trust Us? Without 8 or 9 hours of sleep, most of us end up staggering around like zombies. But ...

Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

Researchers have uncovered a previously unknown mechanism that safeguards the chromosome ends from being mistakenly repaired ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A study published in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single ...