An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins are ...
Most protein-coding genes produce multiple protein isoforms; however, these isoforms are commonly neglected in drug discovery. The expression of protein isoforms can be specific to a disease, tissue ...
The prevalence of RNA binding proteins (RBPs) in regulating alternative splicing (AS) in age-related sensorineural hearing loss (SNHL) is unclear. To address this question, we comprehensively ...
An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins are ...
A team of researchers has identified a mechanism that regulates the production of two different proteins from the same gene. Researchers from the Institute for Neurosciences, a joint center of the ...
The team identified sequence-dependent ribonucleic acid (RNA) splicing abnormalities in roughly 36% of the cases. Here, "sequence-dependent" means that the RNA splicing abnormalities occurred only at ...
Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...
A study in zebrafish shows that neuronal microexons regulate brain activity by modulating cAMP signaling. Loss of these ...
Collaboration with UMass Chan Medical School confirmed FMR1-217 as well as an RNA-targeted mechanism to restore functional FMRP protein to develop potential treatments for FXS QurAlis’ preliminary ...
USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins, ...
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