NFL Week 16 picks straight up and against spread
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There are just three games left in the 2025 NFL regular season, and there are still playoff spots up for grabs. Not only that, but the teams already in the post
Now, he's going up against a Jets defense that just allowed Trevor Lawrence to post six total touchdowns (five passing and one rushing), which led to the firing of defensive coordinator Steve Wilks. Shough shouldn't face much resistance this week, which could make it very hard for undrafted rookie Brady Cook to keep up in his second career start.
NFL Week 16 is here, so let's look at the odds and make some picks and predictions for the coming weekend as the playoffs near.
Week 16 of the 2025 NFL season kicks off with an NFC West divisional battle between the Los Angeles Rams and Seattle Seahawks in Washington on Thursday Night Football and wraps up Monday with the New England Patriots and Baltimore Ravens each looking to reestablish themselves.
Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on "Monday Night Football."
Will Hill delivers his best bet for EVERY NFL Week 16 matchup, beginning with the pivotal NFC West showdown between the Rams and Seahawks.
NFL Week 16 picks, predictions, win probabilities for Buccaneers-Panthers, Jets-Saints, Vikings-Giants, Falcons-Cardinals, Steelers-Lions, more games.