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Chargers vs. Cowboys prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

If Jalen Hurts and the Eagles win against Washington Saturday, Dak Prescott and the Cowboys will be eliminated from playoff consideration. The game pits the Cowboys’ elite passing offense against a Chargers’ defense that has allowed less than 20 points in three straight games and ranks ninth in opposing points per game.

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Chargers-Cowboys Injury Report: Tre’ Harris, Quentin Johnston limited

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Cowboys vs. Chargers prediction, pick, odds for Sunday's NFL Week 16 game - 12/21/2025

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5 reasons for optimism for the Chargers against the Cowboys in Week 16

The Chargers have an opportunity to clinch a playoff spot with a win against the Cowboys on Sunday.

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Who to cheer for in Week 16: A Chargers rooting guide

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Chargers vs. Cowboys: 5 biggest storylines ahead of Week 16 game

Patrick Mahomes injury marks turning point

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Yardbarker on MSN · 2d

What Chargers' Daiyan Henley told Chiefs players after brutal Patrick Mahomes injury

Los Angeles linebacker Daiyan Henley spoke with Albert Breer of Sports Illustrated about the Mahomes injury that will be responsible for one of the most-discussed NFL-related storylines of 2026.

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Chiefs announce troubling new injury timeline for Patrick Mahomes

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Making case why Titans can, and can't, upset Patrick Mahomes-less Chiefs

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Andy Reid Announces Chiefs Setback Amid NFL Season

Andy Reid's Kansas City Chiefs have been hit with several big-time injuries during the NFL season, most notably to quarterback Patrick Mahomes.

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Chiefs’ injuries pile up, especially at wide receiver and on the offensive line

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Chiefs Quarterback Dealt Bad News on Wednesday

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DaRon Bland injury update is devastating news for Cowboys' secondary

Dallas Cowboys All-Pro cornerback DaRon Bland appears to be ending his 2025 NFL campaign early due to a nagging foot injury.

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Chargers sign former Jets, Saints safety after RJ Mickens injury

The Chargers have signed veteran safety Marcus Maye back to the practice squad after playing with the team at the end of last season.

Chargers Urged to Target Veteran Free-Agent Wide Receiver Amid Injury Concerns

With Quentin Johnston sidelined, the Chargers could explore adding veteran wide receiver depth as they push toward the postseason.

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Chargers earn major injury boost before NFL Week 14 meeting with Eagles

The Los Angeles Chargers’ star QB, Justin Herbert, may be bucking the odds and looking to get back under center when the Los Angeles Chargers take on the Philadelphia Eagles in Week 14. Per the Athletic’s Dianna Russini,

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Justin Herbert Is One Thing Away From Becoming Unstoppable In The NFL

The Los Angeles Chargers and quarterback Justin Herbert are 10-4, looking to make a push in the playoffs this season. The Chargers have been in some close games

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Chargers Get Encouraging Injury News on Justin Herbert Ahead of Crucial Matchup with Chiefs

Justin Herbert shared encouraging updates on his repaired hand ahead of Sunday’s crucial game vs. the Kansas City Chiefs.

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Chargers’ Justin Herbert gives update on hand injury after taking a beating vs. Eagles

Chargers quarterback Justin Herbert shared an update on his hand following a grueling Monday night win vs. the Eagles.

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Los Angeles Chargers leader hints at NFL suspension update

This is overall just good news for the Chargers. The safety room is a mess right now. They traded away one player before the deadline. Elijah Molden has been battling an injury and breakout rookie story RJ Mickens suffered an injury last week that could have him missing time.

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Injuries to Patrick Mahomes and Micah Parsons ruin NFL’s Week 15

First, Patrick Mahomes went down. Then, it was Micah Parsons. The NFL lost two of its all-time greatest players to serious knee injuries in a span of a few hours on Sunday, ruining a day filled with exciting comebacks and fascinating stories.