Week 16 of the NFL season began Thursday night with a wild overtime game between the LA Rams and Seattle Seahawks. On Saturday, there were two games. There will be a Sunday night and a Monday night game. The Sunday night game on NBC will be Patriots-Ravens. On Monday on ABC and ESPN is 49ers-Colts.

NFL RedZone — an around-the-horn live highlight show demonstrating all the action on NFL Sunday — is back for Week 16 of the 2025 season.

Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL Week 16 game Dec. 22, 2025.

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.