Now, SportsLine's NFL DFS Optimizer has turned its attention to Saturday's 2025 NFL Week 16 two-game schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Defenses will likely have a significant say in who wins fantasy football championships, so be sure not to overlook the position. Use our updated Week 16 fantasy football defense (DST) rankings for 2025 to pinpoint the best team defense for your lineups.

Here's who you should be thinking about starting and benching ahead of Week 16 as you're looking to make a push for your Fantasy Football championship.

The fantasy football semifinals are upon us. At this point in the season, you can't afford to make any lineup mistakes.

Jahmyr Gibbs has all the qualities fantasy players crave: elite production, explosive playmaking, and an every-down role on one of the NFC’s best offenses. When next year’s draft begins, expect his name to be the first one called.

Week 16 begins with a 'Thursday Night Football' divisional matchup between the Los Angeles Rams and Seattle Seahawks at 8:15 p.m. ET. The likes

The tight end position matters greatly in fantasy football. Tight ends are not as flashy as their route-running counterparts at wide receiver. Most of them do not normally get the same volume of touches as fantasy-relevant running backs.

Jason Myers is not supposed to be the hero of a fantasy season, but here everyone is, being dragged to the playoffs by a kicker in a neon green jersey, somewhere your first-round running back quietly looks away in shame.

ESPN NFL Draft insider Matt Miller confirmed that Indiana Hoosiers quarterback Fernando Mendoza is “very much in play” to be selected No. 1 in the 2026 NFL Draft.

The Browns, Titans and Raiders were disproportionately bad this season, and fantasy managers felt it when sifting through the waiver wire.