The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago Bears in Week 17 and then take on the Seattle Seahawks in Week 18. The Seattle-San Francisco regular-season finale could be the No.

The Chicago Bears will battle the San Francisco 49ers in prime time in Week 17. But what do the oddsmakers think about this matchup?

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

Week 16 of the 2025 NFL season ends tonight with a Monday Night Football game between the San Francisco 49ers and Indianapolis Colts. The Philadelphia Eagles’ chances of getting the No. 1 seed are incredibly slim (like,