The first week of the NFL season has seen some international flavor in recent weeks. Last year, it was the Kansas City Chiefs taking on the Los Angeles Chargers in a heated rivalry game.

49ers tight end George Kittle and pass rusher Nick Bosa had no injury designations, and they indeed will play the season opener.

Los Angeles Rams first-round pick Ty Simpson was listed among the team's inactives ahead of Thursday's matchup against the San Francisco 49ers.

The San Francisco 49ers and LA Rams head to Melbourne in Week 1 for the league's first-ever matchup in Australia.

The Rams and 49ers both released their inactive lists ahead of kickoff on Thursday night, and Los Angeles' includes three rookie draft picks.

Myles Garrett and Mike Evans debuted with their new teams during Thursday night's Week 1 action in Australia. Garrett saw his first action with the Los Angeles Rams while Evans made his debut appearance with the San Francisco 49ers in Melbourne. Thursday's matchup marked the NFL's first regular-season game in Australia.

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The San Francisco 49ers enter Thursday night’s season opener against the Los Angeles Rams in Australia with plenty at stake, according to Colin Cowherd. The NFC West rivals will open their 2026 seasons at Melbourne Cricket Ground in the NFL’s first regular-season game in Australia.