The No. 12 seed in the Midwest, the McNeese State Cowboys (27-6) begin their pursuit of a Cinderella-run in March against the No. 5 seed, the Clemson Tigers (27-6). The Cowboys won the Southland Conference. The Tigers lost to Louisville in the semifinals of the ACC Tournament.

McNeese has already proven it can compete with powerhouse programs, and Douglas Farmer is taking the points with the Cowboys ahead of their Midwest Region clash.

NCAA Tournament bracket picks are being made and correctly predicting a handful of 2025 March Madness upsets is key to winning your NCAA bracket challenges outright. Who are the double-digit seeds that will emerge as 2025 March Madness Cinderellas during the NCAA Tournament 2025?