021160 - Cx3cr1 [CreER] knock-in/knock-out Strain Details
WEBThese mice may have applications in studies requiring conditional gene manipulation in central nervous system microglia, as well as other Cx3cr1-expressing myeloid cell populations. Of note, The Jackson Laboratory also has available Cx3cr1 CreER mice without EYFP expression (Stock No. 020940 ).
005975 - PLP/creER[T] Strain Details - The Jackson Laboratory
WEBTamoxifen administration allows for ablation of predetermined genes in oligodendrocytes and Schwann cells, and will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.
007001 - UBC-Cre-ERT2 Strain Details - The Jackson Laboratory
WEB007001 B6.Cg- Ndor1 Tg(UBC-cre/ERT2)1Ejb /1J When these UBC-Cre-ERT2 mice are bred with mice containing a loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in widespread cells/tissues. In Goodwin et al. 2019 Genome Res. 29:494 , it was discovered that the ...
Mouse Cre-LoxP system: general principles to determine tissue …
WEBDec 31, 2018 · A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre- loxP system and a few commonly used promoters for expression of …
CreERT2 | Taconic Biosciences
WEBThe CreER T2 mouse was developed by Artemis Pharmaceuticals (now Taconic). The model was created by a targeted mutation knock in of high affinity CreER T2 (cre/ESR1) into the Gt(ROSA)26 locus on chromosome 6 in C57BL/6NTac ES cells.
Apln-CreERT:mT/mG reporter mice as a tool for sprouting …
WEBSep 2, 2017 · Apln-CreERT:mT/mG mouse line is a useful tool to differentiate sprouting angiogenesis from whole blood vessels in the investigation of retinal and tumor sprouting angiogenesis in vivo. Peer Review reports. Background. Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels.
Activation of creER recombinase in the mouse calvaria induces …
WEBApr 15, 2021 · Conditional creER-mediated gene inactivation or gene induction has emerged as a robust tool for studying gene functions in mouse models of tissue development, homeostasis, and regeneration.
Transgenic mice exhibiting inducible and spontaneous Cre …
WEBJan 8, 2009 · Results: In this study, we have generated two distinct transgenic mouse lines expressing CreERT, which show 4-hydroxytamoxifen (4-OHT)-inducible and spontaneous (4-OHT-independent) Cre activities, referred to …
Cx3Cr1-Cre induction leads to microglial activation and ... - Cell Press
WEBJan 18, 2022 · TAM induction in Cx3cr1 +/CreER mice at early postnatal stages resulted in ∼50% reduction in microglia (Figures 1 B, 1C, and S1 A), along with increased surface expression of CD45, CD11b, and major histocompatibility complex class II (MHC class II) (Figures 1 D–1G), indicating microglial activation.
Gcg CreERT2 knockin mice as a tool for genetic manipulation in ...
WEBThe newly developed Gcg CreERT2 knockin mouse shows faithful expression of CreER T2 in pancreatic alpha cells, intestinal L cells and GLP-1-producing neurons. This mouse line will be particularly useful for manipulating genes in alpha cells, due to …
Skip to content