Old mice grow young again in study. Can people do the same?
WEBJan 12, 2023 · CNN — In Boston labs, old, blind mice have regained their eyesight, developed smarter, younger brains and built healthier muscle and kidney tissue. On the flip side, young mice have prematurely...
Two research teams reverse signs of aging in mice - Science
WEBJan 13, 2023 · The mice ended up with an epigenetic signature more like that of older animals, and their health deteriorated. Within weeks, they lost hair and pigment; within months, they showed multiple signs of frailty and tissue aging.
A metabolome atlas of the aging mouse brain - Nature
WEBOct 15, 2021 · We here present the atlas of the aging mouse brain with an emphasis on the anatomical resolution of 10 brain regions and temporal coverage over the life period from adolescence (AD) to old...
Loss of Epigenetic Information Can Drive Aging, Restoration Can …
WEBJan 12, 2023 · A 13-year study by David Sinclair and colleagues shows that epigenetic changes, not DNA mutations, are the main cause of aging in mice. The team developed a gene therapy that restored the epigenome and rejuvenated the mice.
A single-cell transcriptomic atlas characterizes ageing ... - Nature
WEBJul 15, 2020 · A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis, provides molecular information about the hallmarks of ageing in a range of tissues and cell types.
A lipidome landscape of aging in mice | Nature Aging
WEBApr 12, 2024 · Our study elucidates comprehensive lipidomic alterations associated with aging in mice across four groups: male/SPF, male/GF, female/SPF and female/GF.
Study of Longitudinal Aging in Mice: Presentation of Experimental ...
WEBDec 18, 2020 · Therefore, the Study of Longitudinal Aging in Mice (SLAM) was implemented in order to collect repeated measures on functional, phenotypic, and biological changes over time, and to identify biomarkers that predict morbidity and mortality across 2 different strains of mice of both sexes (Figure 1).
Atlas of the aging mouse brain reveals white matter as vulnerable …
WEBAug 16, 2023 · Here, we conducted spatiotemporal RNA sequencing of the mouse brain, profiling 1,076 samples from 15 regions across 7 ages and 2 rejuvenation interventions. Our analysis identified a brain-wide gene signature of aging in glial cells, which exhibited spatially defined changes in magnitude.
Mouse aging cell atlas analysis reveals global and cell type …
WEBApr 13, 2021 · Aging is associated with complex molecular and cellular processes that are poorly understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to systematically characterize gene expression changes during aging across diverse cell types in the mouse.
Functional Aging in Male C57BL/6J Mice Across the Life-Span: A ...
WEBAug 2, 2021 · To better understand age-related changes across the life-span, we characterized functional aging in male C57BL/6J mice of five different ages (3, 6, 12, 18, and 22 months of age) using a multi-domain behavioral test battery.